Brian S J Blagg Selected Research

HSP90 Heat-Shock Proteins (Heat-Shock Proteins, HSP90)

11/2021	The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with pan-Hsp90 Inhibition.
10/2021	Structure-Based Design, Synthesis, and Biological Evaluation of Hsp90β-Selective Inhibitors.
5/2009	To fold or not to fold: modulation and consequences of Hsp90 inhibition.
6/2007	Hsp90: a novel target for the disruption of multiple signaling cascades.
6/2004	Biotinylated geldanamycin.

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Brian S J Blagg Research Topics

Disease

63	Neoplasms (Cancer) 12/2021 - 06/2004
18	Breast Neoplasms (Breast Cancer) 01/2020 - 11/2004
11	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2021 - 04/2007
11	Peripheral Nervous System Diseases (PNS Diseases) 01/2021 - 08/2010
5	Neoplasm Metastasis (Metastasis) 03/2021 - 06/2007
5	Glaucoma 03/2021 - 11/2012
5	Prostatic Neoplasms (Prostate Cancer) 01/2017 - 09/2005
4	Alzheimer Disease (Alzheimer's Disease) 01/2017 - 04/2007
3	Open-Angle Glaucoma (Glaucoma, Open Angle) 01/2018 - 12/2014
3	Multiple Myeloma 10/2017 - 08/2014
2	Inflammation (Inflammations) 01/2021 - 01/2021
2	Pain (Aches) 01/2020 - 01/2019
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2019 - 04/2012
2	Hyperglycemia 01/2019 - 04/2012
2	Demyelinating Diseases (Demyelinating Disease) 01/2018 - 12/2012
2	Type 2 Diabetes Mellitus (MODY) 02/2014 - 01/2012
1	Cardiovascular Diseases (Cardiovascular Disease) 12/2021
1	Ischemia 12/2021
1	Virus Diseases (Viral Diseases) 03/2021
1	Disease Progression 01/2021
1	follicular Thyroid cancer 01/2021
1	Melanoma (Melanoma, Malignant) 01/2021
1	Thyroid Neoplasms (Thyroid Cancer) 01/2021
1	Skin Neoplasms (Skin Cancer) 01/2021
1	Tuberculosis (Tuberculoses) 12/2020
1	Adrenocortical Carcinoma 01/2020
1	Tics (Tic) 01/2020
1	Oncogene Addiction 01/2020
1	Obesity 01/2019
1	Shock 01/2019
1	Paraparesis 01/2018
1	Tauopathies 01/2017

Drug/Important Bio-Agent (IBA)

40	Proteins (Proteins, Gene)FDA Link 12/2021 - 11/2004
28	Heat-Shock Proteins (Heat-Shock Protein)IBA 12/2021 - 09/2006
21	Novobiocin (Streptonivicin)FDA Link 01/2021 - 09/2005
15	Molecular Chaperones (Chaperone, Molecular)IBA 11/2021 - 09/2006
12	glucose-regulated proteinsIBA 03/2021 - 11/2012
10	Pharmaceutical PreparationsIBA 01/2021 - 01/2008
9	Protein Isoforms (Isoforms)IBA 11/2021 - 02/2015
9	NAD (NADH)IBA 01/2021 - 08/2010
8	Biological ProductsIBA 06/2011 - 01/2006
5	HSP90 Heat-Shock Proteins (Heat-Shock Proteins, HSP90)IBA 11/2021 - 06/2004
5	trabecular meshwork-induced glucocorticoid response proteinIBA 01/2018 - 11/2012
4	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 06/2004
4	tanespimycin (17AAG)IBA 01/2020 - 01/2006
4	KU-596IBA 01/2019 - 08/2014
4	AmidesIBA 10/2016 - 06/2009
4	LuciferasesIBA 07/2015 - 10/2011
3	Oncogene Proteins (Oncogene Protein)IBA 06/2021 - 10/2013
3	benzamideIBA 01/2017 - 03/2008
3	geldanamycinIBA 06/2009 - 01/2006
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2021 - 01/2018
2	EnzymesIBA 01/2021 - 01/2018
2	Adenosine Triphosphate (ATP)IBA 12/2020 - 09/2010
2	Opioid Analgesics (Opioids)IBA 01/2020 - 01/2019
2	Morphine (MS Contin)FDA LinkGeneric 01/2020 - 01/2019
2	Superoxides (Superoxide)IBA 01/2019 - 04/2012
2	olfactomedinIBA 01/2018 - 12/2014
2	SugarsIBA 10/2016 - 12/2011
2	Neuroprotective AgentsIBA 08/2016 - 08/2014
2	Antineoplastic Agents (Antineoplastics)IBA 07/2015 - 06/2006
2	AndrogensIBA 07/2015 - 10/2011
2	geduninIBA 03/2013 - 10/2008
2	Adenosine Triphosphatases (ATPase)IBA 12/2012 - 11/2004
2	PlatinumIBA 07/2012 - 01/2008
2	Insulin (Novolin)FDA Link 03/2012 - 01/2012
2	novioseIBA 12/2011 - 07/2010
2	Peptides (Polypeptides)IBA 05/2009 - 02/2009
2	Protein AggregatesIBA 02/2009 - 04/2007
2	tau Proteins (tau Protein)IBA 02/2009 - 04/2007
2	coumarinIBA 03/2008 - 10/2006
2	monorden (radicicol)IBA 05/2006 - 01/2006
1	Transcription Factors (Transcription Factor)IBA 12/2021
1	Mitogen-Activated Protein KinasesIBA 01/2021
1	vanillinIBA 01/2021
1	Complement System Proteins (Complement)IBA 01/2021
1	CurcuminIBA 01/2021
1	DNA Polymerase thetaIBA 01/2021
1	VemurafenibIBA 01/2021
1	HarmalineIBA 01/2021
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2021
1	cobimetinibIBA 01/2021
1	methyl tert-butyl ether (MTBE)IBA 01/2021
1	lenvatinibIBA 01/2021
1	PromegaIBA 01/2021
1	bedaquiline (R207910)IBA 12/2020
1	DNA GyraseIBA 08/2020
1	benzothiazoleIBA 08/2020
1	Long Noncoding RNAIBA 01/2020
1	CateninsIBA 01/2020
1	TOR Serine-Threonine KinasesIBA 01/2020
1	Aldehyde DehydrogenaseIBA 01/2020
1	mu Opioid Receptors (mu Opioid Receptor)IBA 01/2019
1	Protein Tyrosine PhosphatasesIBA 01/2019
1	Analgesics (Analgesic Drugs)IBA 01/2019
1	(2,4- dihydroxy- 5- isopropylphenyl)- (5- (4- methylpiperazin- 1- ylmethyl)- 1,3- dihydroisoindol- 2- yl)methanoneIBA 01/2019
1	Tamoxifen FDA LinkGeneric 01/2018

Therapy/Procedure

9	Therapeutics 01/2020 - 05/2012
3	Drug Therapy (Chemotherapy) 01/2021 - 04/2015
1	Immunotherapy 01/2021